Analytical Standards

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Shimadzu Chemistry & Diagnostics, a Shimadzu Group Company, is one of the world leaders in the synthesis of stable labeled (13C, 2H, 15N) internal standards, stable labeled building blocks, APIs (Active Pharmaceutical Ingredient) and metabolites used in Bioanalysis studies. Based on its expertise, Shimadzu Chemistry & Diagnostics develops also Therapeutic Drug Monitoring (TDM) devices to support hospitals and bioanalysis centers to their daily work and routine operation.

Health & Clinical Forensic & Toxicology Doping agents Environment Food & Beverages


 

Shimadzu Chemistry & Diagnostics offers a comprehensive Certificate of Analysis including chemical purity determined by HPLC/UV analysis, LC/MS analysis, Mass spectrum, 1H, 13C, 19F, 31P NMR spectra.

Shimadzu likes to emphasize and guarantee the highest performance of our advanced LC- and GC-MS instruments by supplying selected Shimadzu Chemistry & Diagnostics products to our customers in different applications.


 

Food
clinic
Compound Selections for Environment / Food & Beverages: Compound Selections for Clinical:
Glyphosate Covid-19 Drugs
Chlorpyrifos-methyl 5 Fluorouracil
  [13C6]Thiotepa


 

Glyphosate

The detection is now possible

Glyphosate has been used for decades as a powerful herbicide all over the world. Recent studies and laws have made the use of this herbicide controversial and its consequences on human health questionable. The detection and quantification of glyphosate and its main metabolite, the aminomethylphosphonic acid (AMPA), is now mandatory to ensure the public’s health safety.

Shimadzu Chemistry & Diagnostics offers the standards you need for your analysis:

Product Name Pack of 1 mg pack of 10 mg
Glyphosate ALC-C6552-01 ALC-C6552-02
[13C3,2H2]-Glyphosate ALC-C338-01 ALC-338-02
[13C3,15N]-Glyphosate ALC-C339-01 ALC-C339-02
AMPA ALC-C7474-01 ALC-C7474-02
[13C,15N,2H2]-AMPA hydrochloride salt ALC-4314-01 ALC-C4314-02

All products are delivered with a detailed Certificate of Analysis 

 

Chlorpyrifos-methyl

The quantification is within your reach

Chlorpyrifos-methyl is a powerful pesticide, it has proven its efficiency and utility throughout the years. With this use comes a big risk for consumers. Therefore, the European Commission has revised downward the maximum residue levels of chlorpyrifos-methyl authorized in the European Union. In order to ensure a good level of the new MRLs recommended in the EU, we offer you now the possibility not only to quantify the levels of the pesticide active substance chlorpyrifos-methyl but also for its metabolite desmethyl chlorpyrifos-methyl.

 

Product Name Pack of 1 mg Pack of 10 mg
[2H10]-Chlorpyrifos ALC-C7740-01 ALC-C7740-02
Chlorpyrifos-methyl ALC-C8016-01 ALC-C8016-02
Desmethyl chlorpyrifos-methyl ALC-C8018-01 ALC-C8018-02

 All products are delivered with a detailed Certificate of Analysis

 

COVID-19 Drugs

Internal standards for therapeutic drug monitoring of potential COVID-19 drugs

Many laboratories and hospitals around the world are carrying out studies to find a solution against the spread of COVID-19 virus. Several drugs are on the test bench such as Hydroxychloroquine, Favipiravir or Remdesivir. Used alone or in combination with other drugs, these molecules demonstrate promising results. In order to develop and set up dosage methods, e.g. to determine the optimal doses, clinical studies based on therapeutic drug monitoring by LC-MS will be needed.

An Europe-wide clinical trial, called "Discovery", was launched to test four experimental treatments for COVID-19, including the following compounds: Remdesivir, Lopinavir and Ritonavir, Hydroxychloroquine. This trial will also complement the data that will be collected during another international clinical trial, called "Solidarity". Shimadzu and Shimadzu Chemistry & Diagnostics are supporting these clinical trials by providing internal standards for therapeutic drug monitoring of these potential anti-COVID-19 drugs.

 

Related Drug Product Name Pack of 1 mg
Favipiravir Favipiravir ALC-C8720-01
[13C,15N]-Favipiravir ALC-C8853-01
Lopinavir and Ritonavir Lopinavir ALC-C2745-01
[2H8]-Lopinavir ALC-C4693-01
Ritonavir ALC-C2792-01
[13C,2H3]-Ritonavir ALC-C2963-01
Remdesivir and GS 441524
(Active Metabolites of Nucleoside
analog, Remdesivir)		 Remdesivir ALC-C8799-01
[13C6]-Remdesivir (Mixture of Diastereoisomers) ALC-C8854-01
GS 441524 / CAS 1191237-69-0 ALC-C8847-01
[13C5]-GS 441524 ALC-C8855-01
Chloroquine and  Hydroxychloroquine Chloroquine diphosphate ALC-C1741-01
[2H5]-Chloroquine oxalate salt ALC-C5023-01
Hydroxychloroquine sulfate ALC-C4600-01
[2H5]-Hydroxychloroquine dioxalate salt [2H5]-Hydroxychloroquine dioxalate salt ALC-C6422-01
Desethylchloroquine diphosphate ALC-C2331-01
[2H5]-Desethylchloroquine dioxalate salt ALC-C2453-01
Azithromicin Azithromycin dihydrate ALC-C1746-01
[13C,2H3]-Azithromycin ALC-C1768-01
Nafamostat Mesylate Nafamostat Mesylate ALC-C8848-01
[13C6]-Nafamostat Mesylate ALC-C8849-01

 All products are delivered with a detailed Certificate of Analysis

 

5 Fluoro-uracil

Detect DPD’s deficiency

5-Fluorouracil is one of the most administrated drugs for the treatment of solid cancers. The use of this drug induces severe toxicities caused mainly by the deficiency of the enzyme dihydropyrimidine dehydrogenase (DPD), therefore a pretreatment assessment is necessary.
Shimadzu Chemistry & Diagnostics offers you the standards you need for the quantification of dihydrouracil to uracil ratio in plasma and also for a continuous follow-up of 5-fluorouracil doses.

You can order now the standards you require to start your bioanalysis.

 

Product Name Pack of 1 mg Pack of 10 mg
Uracil ALC-C7820-01 ALC-C7820-02
[13C,15N2]-Uracil ALC-M150-01 ALC-M150-02
Dihydrouracil ALC-C4687-01 ALC-C4687-02
[13C,15N2,2H4]-Dihydrouracil ALC-C4677-01 ALC-C4677-02
[13C,15N2]-Dihydrouracil ALC-C7849-01 ALC-C7849-02
5-Fluorouracil ALC-C6519-01 ALC-C6519-02
[13C,15N2]-5-Fluorouracil ALC-C2086-01 ALC-C2086-02

 All products are delivered with a detailed Certificate of Analysis

 

Thiotepa

Shimadzu Chemistry & DiagnosticsStable Labeled standard

Thiotepa is an alkylating agent with potent anti-lymphoma properties. It has been used for high dose chemotherapy and autologous hematopoietic cell transplantation. With its central nervous system penetration, it has been continously studied for malignancies and drug interactions.

Shimadzu Chemistry & Diagnostics gives you the opportunity for the first time in the market to get a hold of this stable labeled standard:

 

Product Name Pack of 1 mg Pack of 10 mg
[13C6]-Thiotepa ALC-C264-01 ALC-C264-02
Thiotepa ALC-C5393-01 ALC-C5393-02

 

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