Micro-Flow LC-MS System

Key-Features

• Increased sensitivity
• Reduced sample volume
• Unsurpassed robustness
• User friendly

Sensitivity enhancement for lipid mediators with micro-flow LCMS

Technical report

Development of micro-flow ESI for high sensitivity with high robustness

Brochure

Nexera Mikros – new micro-flow LCMS system

System Configuration Options

Direct Injection System - Trap and Elute System - Make-Up Flow System

Increased Sensitivity of a Micro-Flow System with the Ruggedness of Standard HPLC

User-Benefits

• Increased sensitivity provides lower LOQs for more accurate quantitation in DMPK studies and lower LODs for detection of novel biomarkers
• Micro sampling is less invasive to the patient while saving cost for delivery and storage
• Ruggedness and ease of use of Nexera-Mikros increase throughput and lab efficiency

Nexera™ Mikros and nSMOL™ Antibody BA Kit

Background

• The nSMOL Antibody BA Kit is a ready-to-use reagent kit for collecting monoclonal antibodies from blood or other biological samples
• Fab-derived peptides are quantified via MRM measurement on a high-sensitivity mass spectrometer.
• Nexera Mikros achieved signal intensities 12 times higher than with conventional flow rates, with a corresponding lower limit of detection of 0.025 μg/mL and good linearity.
• The Nexera Mikros system is ideal for low-level quantitation of peptides by LCMS.