DPiMS-2020 for a Wide Variety of Applications

Analysis of Components in Surfactant Mixtures

 

An example of the screening of complex mixtures of cosmetics and personal care products in full-scan mode is shown below. Changes in spectral results indicate corresponding changes in composition. Samples can often be deposited directly onto the sample plate.

 

 

 

Real-Time Monitoring of Reactions for Peptide Synthesis (Deprotection)

 

Fmoc deprotection is an essential step in peptide synthesis. The example below shows real-time monitoring of reaction completion performed using PESI. Fmoc cleavage was determined by monitoring the depletion of the source material, represented by m/z 458.2. By sampling trace quantities with the probe, real-time monitoring is possible without altering the sample status.

 

 

Recommendations regarding data acquisition and sample preparation methods were contributed by Dr. Kei Zaitsu, associate professor and Dr. Yumi Hayashi, assistant professor of Graduate School of Medicine, Nagoya Univ.

 

Detection of Cyanide in Serum

 

Analytical methods that can be performed immediately with only simple pretreatment are especially desirable in fields such as forensics. The following is an application for rapid screening of biomaterial samples suspected to contain cyanide compounds. Derivatizing agents (taurine and naphthalenedialdehyde) were added to a serum sample containing a trace quantity of cyanide, and the mixture was measured using a DPiMS-2020 system. In-source CID was used to enhance detection limits. Since only 10 μL of serum was used, limited serum sample was preserved for other necessary tests.

 

 

Reference 1: S. Chinaka, N. Takayama, Y. Michigami, and K. Ueda. J. Chromatogr. 713: 353-359 (1998)
Recommendations regarding data acquisition and sample preparation methods were contributed by Dr. Kei Zaitsu, associate professor and Dr. Yumi Hayashi, assistant professor of Graduate School of Medicine, Nagoya Univ.

 

Evaluating Dietary Supplements

 

Foods such as fish contain large amounts of DHA or other polyunsaturated fatty acids; however, it can be difficult to obtain adequate quantities in a standard diet. Consequently, they are available as dietary supplements in capsule form. These compounds are susceptible to oxidation by heat or UV exposure. In this example, UV exposure and subsequent oxidation of DHA and EPA contained in supplements was easily confirmed by PESI analysis without extensive sample preparation.