Saving time saves lives
Saving time saves lives

Complete solution for automated immunosuppressant analysis with a Ready-to-use kit and a robotic Liquid Handler.

In Vitro Diagnostic (IVD)

DOSIMMUNE™ kit (CE-IVD)

Ready-to-use turnkey solution

DOSIMMUNE™ kit (CE-IVD)

The DOSIMMUNE™ kit

Hamilton Microlab STAR Liquid Handling System

(*) Example: Hamilton Microlab STAR Liquid Handling System (IVD device is in preparation) 

  • Highly reliable – metrological traceability chain
  • Easy to set on Liquid Handler*
  • Methods and documentation
  • Complete documentation including manual with analytical and sample preparation methods, safety data sheets, certificates of analysis, expiry dates, etc.

Automated sample preparation

High-throughput

Automated sample preparation

LC/MS/MS analysis: 1.5 min per sample

Shimadzu LC-MS/MS CE-IVD devices

Shimadzu offers Liquid Chromatography and Mass Spectrometry medical devices

Shimadzu LC-MS/MS CE-IVD devices

Shimadzu LC-40 CL series and LCMS-8045 CL / 8050 CL / 8060 CL / 8060NX CL (CE-IVD devices)

Stable Data (Analysis using Shimadzu LC/MS/MS)

Stable Data
  • The ISTD in the DOSIMMUNE™ kit can be mixed with the extraction buffer, and mixture can be delivered through the Liquid Handler’s automated supply unit.
  • As a result, there is little ISTD area variation for any of the immunosuppressants throughout the three 96-well plates, with a %RSD of less than 5.8 % (n = 288).
  • The method, including automated sample preparation, has been fully validated following international bioanalytical guidelines (ICH M10), including from the Clinical and Laboratory Standards Institute (CLSI C62-A).

Shimadzu's Complete Solution in Action

Faster throughput. Together.

Secrets of Science 01/2023

To face increasing demands on their time and resources, chemical laboratories need easier-to-handle solutions with faster turnaround times, lower costs per sample and full compliance with ever-stricter regulatory standards. Recent work by Alsachim using Shimadzu equipment and software has now led to an optimized high-throughput analytical solution that delivers same-day results for therapeutic drug monitoring of immunosuppressants. The solution combines liquid chromatography and tandem mass spectrometry (LC-MS/MS) with automated sample preparation and a dedicated reagent kit.

Would you like more information about Shimadzu's complete solution for automated immunosuppressant analysis?