The DOSIMMUNE™ kit is a ready-to-use kit for simultaneous quantification of four key immunosuppressant drugs in whole blood.
Complete solution for automated immunosuppressant analysis with a Ready-to-use kit and a robotic Liquid Handler.
In Vitro Diagnostic (IVD)
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The DOSIMMUNE™ kit is easy to set on Liquid Handler. High throughput is achieved by automation with liquid handlers.
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Shimadzu's LCMS-TQ is fast, sensitive, and high-resolution, with excellent performance and robustness for high-throughput analysis.
DOSIMMUNE™ kit (CE-IVD)
Ready-to-use turnkey solution
The DOSIMMUNE™ kit
(*) Example: Hamilton Microlab STAR Liquid Handling System (IVD device is in preparation)
- Highly reliable – metrological traceability chain
- Easy to set on Liquid Handler*
- Methods and documentation
- Complete documentation including manual with analytical and sample preparation methods, safety data sheets, certificates of analysis, expiry dates, etc.
Automated sample preparation
High-throughput
LC/MS/MS analysis: 1.5 min per sample
Shimadzu LC-MS/MS CE-IVD devices
Shimadzu offers Liquid Chromatography and Mass Spectrometry medical devices
Shimadzu LC-40 CL series and LCMS-8045 CL / 8050 CL / 8060 CL / 8060NX CL (CE-IVD devices)
Stable Data (Analysis using Shimadzu LC/MS/MS)
- The ISTD in the DOSIMMUNE™ kit can be mixed with the extraction buffer, and mixture can be delivered through the Liquid Handler’s automated supply unit.
- As a result, there is little ISTD area variation for any of the immunosuppressants throughout the three 96-well plates, with a %RSD of less than 5.8 % (n = 288).
- The method, including automated sample preparation, has been fully validated following international bioanalytical guidelines (ICH M10), including from the Clinical and Laboratory Standards Institute (CLSI C62-A).
Shimadzu's Complete Solution in Action
Faster throughput. Together.
To face increasing demands on their time and resources, chemical laboratories need easier-to-handle solutions with faster turnaround times, lower costs per sample and full compliance with ever-stricter regulatory standards. Recent work by Alsachim using Shimadzu equipment and software has now led to an optimized high-throughput analytical solution that delivers same-day results for therapeutic drug monitoring of immunosuppressants. The solution combines liquid chromatography and tandem mass spectrometry (LC-MS/MS) with automated sample preparation and a dedicated reagent kit.