Sensitivity

 

Sensitivity

 

By redefining the ion focusing capability on the UF-Qarray, the LCMS-8060 brings a meaningful impact to quantitative detection and opens new opportunities for scientists to deliver solutions that make a true difference. The newly developed UF-Qarray ion guide is a groundbreaking technology that increases LC/MS/MS sensitivity by enhancing ion signal intensity and reducing noise. By improving the ion sampling device, the ion guide, and the vacuum efficiency, the LCMS-8060 delivers a new vision of sensitivity and makes a real difference to working better and faster.

 


MRM chromatograms : 100 mg/mL neat standard, upper : signal comparison, lower : baseline noise comparison

 

Built on the proven platform of the LCMS-8050, the new patented ion guides developed for the LCMS-8060 greatly improves ion production and collisional focusing without affecting noise.
The ion production, transmission and detection of three pesticides (fenoxaprop-ethyl, clofentezine and triclopyr) results in increased sensitivity compared to previous technologies.

 

 

The chromatogram for each pesticide has been magnified to show the noise has not increased with a higher ion production. Innovations in ion guide technologies not only delivers new limits of MRM sensitivity but has an impact on full-scan sensitivity.

 


Comparison between the LCMS-8060 (purple) and LCMS-8050 (blue) for the analysis of lipids (precursor ion scanning at m/z 184-choline-containing phospholipids in positive ion mode)

 

Lipid profiling on the LCMS-8060 can detect more ion signals with greater precision and with higher confidence. After protein precipitation, the human serum sample was diluted 1000 times by methanol and 1uL was injected onto the LCMS-8050 and LCMS-8060 systems using a scan speed of 3,000 u/sec. With the LCMS-8060 lower levels of phosphatidylcholine could be detected in a human serum sample following a protein crash sample preparation compared to the LCMS-8050.

 

 

For Research Use Only. Not for use in diagnostic procedures.

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