Applications: Advanced Medical Equipment Fields

Applications: Advanced Medical Equipment Fields

  • The drug release process in drug delivery systems
  • The generation and disappearance process of microbubbles, which are utilized for sterilization and ultrasound diagnosis

In medical treatment and biotechnology fields, research is advancing using the dynamics of so-called microbubbles, microscopic bubbles on the order of 1 to 100 microns. When microbubbles in a fluid are exposed to ultrasonic waves, they expand, contract, and then disappear, a process that generates a localized, high-speed flow referred to as a microjet. Research is being performed regarding the use of this phenomenon to open pores in cells so as to introduce genes and pharmaceutical agents directly into cells. Microbubbles are extremely minute, so the process of expansion, contraction, and destruction occurs at very high speeds. Accordingly, a high-sensitivity, high-speed camera is required to analyze this behavior. In addition, high-speed cameras are used to observe the behavior of ultrasonic waves from ultrasonic generators.

The Destruction Process of Microbubbles in Proximity to Cancer Cells Using Ultrasonic Waves

Research is advancing into a drug delivery system in which microcapsules containing pharmaceutical agents and microbubbles are introduced in proximity to cancer cells. Exposure to ultrasonic waves is used to rupture the capsules, and the pharmaceutical agents are then guided into the cancer cells. The images illustrate the expansion, contraction, and destruction of microbubbles in proximity to cancer cells, and the mechanical impact of this process on the cells. (Provided by Division of Bioengineering and Bioinformatics at Hokkaido University) Recording speed: 10 million frames/second Width of field of view: Approx. 130 μm

High-Speed Contraction of Microbubbles

The images illustrate the contraction and disappearance of microbubbles resulting from an electrical discharge at the tip of a microscopic tube. Research is being conducted into micro-scalpels and other applications using the high-speed flow generated when microbubbles disappear. (Provided by the Yamanishi Laboratory at the Shibaura Institute of Technology) Recording speed: 5 million frames/second Width of field of view: Approx. 0.2 mm

For Research Use Only. Not for use in diagnostic procedures.

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