LC-MS kit for DPD deficiency check in plasma

DOSIURA for LC-MS DPD deficiency check in plasma

Alsachim, a Shimadzu Group Company, developed DOSIURA, the first turnkey solution for the rapid and multiplex assay of uracil and dihydrouracil by LC-MS/MS for indirect phenotyping of dihydropyrimidine dehydrogenase (DPD) deficiency. Based on MRM technology and the use of stable labeled internal standards developed in-house by Alsachim, the DOSIURA solution enables simultaneous quantification of uracil and dihydrouracil.
This kit is ready-to-use with all the components and accessories required to monitor the quantification of uracil and dihydrouracil in plasma measurement by Liquid Chromatography coupled to tandem Mass Spectrometry (LC-MS/MS) .

DOSIURA a turnkey solution:


Solution for LC-MS DPD deficiency check in plasma

  • 3 sets composed by: calibrator with 6 levels and blank, internal standards and quality control with 3 levels
  • ready-to-use consumables: mobile phases, system cleaning solution, extraction buffer, analytical column, LC vials and microtubes


DOSIURA is available for 200 analysis and delivered with all documentation (analytical and sample method, quality data sheet, etc.).
The solution for 200 analyses is composed of: mobiles phases A & B, cleaning solution, extraction buffer, quality controls, calibrators, internal standards, analytical column.

The DOSIURA solution can be customized tailored to your specific requirements (number of analysis). Please contact us to explain your specific needs or to arrange a demo:

DOSIURA benefits:

  • Standardized and time-saving
  • Ready-to-use
  • Supported by the manufacturer
  • Consistent QC material available

Order information:

RUO Version Components Qty (suggested for 200 analysis)
227-40702-58 DOSIURA, Mobile Phase A (280 mL) 4
227-40703-58 DOSIURA, Mobile Phase B (1 L) 1
227-40704-58 DOSIURA, System Cleaning Phase (1 L) 1
227-40705-58 DOSIURA, Extraction Buffer (100 mL) 1
227-40706-58 DOSIURA, Internal Standard Set (lyoph.) 1
227-40710-58 DOSIURA, Calibrator Set (lyoph. 6 Levels + Blank) 1
227-40720-58 DOSIURA, Control Set (lyoph. 3 Levels) 1
227-40742-58 DOSIURA, Column Set 1
RUO Version Optional parts
227-40740-58 DOSIURA, Labeled Tuning Mix
227-40741-58 DOSIURA, Unlabeled Tuning Mix
227-40335-58 DOSIURA, Microtubes (500 units)
227-40743-58 DOSIURA, LC PP Vial Set (100 units)

DOSIURA is a registered trademark of Shimadzu. This page may contain references to products that are not available in your country. This product could be available for research use only depending of your country. Please contact us to check the availability of these products in your country:

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