Engineered for Robustness and Easy Operation/Maintenance

 

Long term stability study on LCMS-8060

 

The robustness of the LCMS-8060 and modified ion optics was also assessed by injecting 2400 samples of femto-gram levels of alprazolam spiked into protein-precipitated human plasma extracts over a 6 day period (over 400 samples were injected each day). The RSD of peak area response was 5% over this test period, using a deuterated internal standard (alprazolam-d5) the RSD was 3.5%. As part of the robustness test the vacuum system was vented to model a transient power failure with no effect on signal response or baseline noise level.

 


MRM chromatograms for the 1st, 1200th and 2400th measurements of alprazolam

 

 

Compound (%RSD) Inter-Day Variation
1st day 2nd day 3rd day 4th day 5th day 6th day Days 1-3 Days 4-6 6 Day Total
alprazolam 5.04 4.94 5.06 5.38 4.55 4.83 3.19 1.63 2.74
alprazolam-d5 (ISTD) 5.04 4.68 5.48 5.31 4.26 4.91 2.62 1.89 2.18
Area ratio (alprazolam / alprazolamd5) 3.48 3.11 3.48 3.44 3.71 3.54 1.79 0.26 1.40

 

Easy System Maintenance Reduces Downtime

 

As with Shimadzu’s other triple quad systems, maintaining the LCMS-8060 is simple. Replacing the desolvation line (DL) and ESI capillary is quick and easy. Additionally, the design allows users to replace the DL without breaking vacuum, providing greater uptime and usability.

Steps for DL Replacement

 

 

Newly Designed Ionization Unit

 

Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.

 

For Research Use Only. Not for use in diagnostic procedures.

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