IATDMCT 2024

15.09.2024 - 18.09.2024
Banff Centre for Arts and Creativity

Meet Shimadzu at IATDMCT!

Shimadzu's technologies are used in the clinical environment both for daily routine analysis and for research and development of ultra-early diagnostics, diagnostics, medical treatments and prognostic phases. The axes of development are cancer, diseases related to lifestyle in order to be in better health for longer, as well as neurodegenerative diseases. With longstanding expertise in medical imaging as well as analytical instrumentation, Shimadzu is perfectly positioned to offer innovative and robust mass spectrometry-based solutions for therapeutic drug monitoring applications, toxicology studies, biomarker research and monitoring of new drugs based on monoclonal antibodies. Visit the Shimadzu booth at IATDMCT-2024 and chat with our experts to learn about all the solutions offered!

 

 

Workshop

Title:	Automated LCMS-Solution Ready for 24/7
Date:	Tuesday, September 17, 11:30-12:30
Lecturer	Dr.rer.nat. Frank Streit Institute of Clinical Chemistry / UMG-Laboratories, University Medical Center Göttingen
Abstract	CLAM 2040 Nice Toy or a Game Changer The Clinical laboratory automated module CLAM-2040 connected to a SIL-40-HPLC-LC-MS/MS instrument allows a fully automated measurement of hundreds of compounds using several multiparametric LC/-MS/MS methods. A HL7-Interface connected to the LIS reads the barcodes on the sample tubes asking the LIS for request and starts sample preparation, analysis, determination and submits the results automatically. The measurements can easily performed by technicians without special chromatographic or mass spec experience. An Introduction into the philosophy for using CLAM instrumentation will be given as follows: The CLAM is and will be in future an open user instrumentation for a 24/7 available LCMS-Determination for various applications which can be implemented by users itself. It allows specialists to setup new analytical request and the implementation into clinical routine measurement within a very short time. Up to now there are several applications note available to be implemented by users or field application specialists from Shimadzu. In addition there will be also IVDR test KITs available in near future from different vendors, which shows that request for such instrumentation is coming up. A chrash course how to establish such a test kit on CLAM-2040 may convince to introduce CLAM-2040 in your laboratory. Starting calibration and qc-samples as well as starting patient sample measurement can be performed with an intuitive user-friendly interface. Quality control sheet can be used for fast qc-results check. Validation data for antibiotics, antiepileptics, antidepressant, antimycotics, DOACs convince with their accuracy, long term calibration stability and robustness even in random measurement order.  Automated peak identification quantification and validation of results for requested compound or unknown screening allows to run LC-MS/MS methods by non-special LC-MS skilled personel using the HL7-Interface.

Dr. Frank Streit

Dr. Frank Streit established LC-MS/MS methods for the quantification of immunosuppressants in the mass spectrometry laboratory at the University of Göttingen and started lc-ms/ms routine quantification of Sirolimus and Everolimus in 1999 and of Tacrolimus and Ciclosporin in 2004. To date, he has led the development of LC-MS/MS methods for the quantification of more than 300 compounds for TDM. In 2017, Shimadzu's CLAM/LCMS, the world's first fully-automated LCMS system, was used to introduce routine testing methods for antibiotic drugs in his laboratory. From 2020, as one of Shimadzu's European Innovation Centers, it will play a leading role in the development of fully automated routine methods for screening and TDM as diagnostic and therapeutic monitoring methods in the context of personalized medicine. This workshop will present fully automated LCMS solutions for routine testing.

 

 

 

Posters

Analysis of Antimycotics in Serum / Plasma Using RECIPE® ClinMass® TDM Kit with Fully Automated Sample Preparation LC/MS/MS System

A.Grüning¹, A. Kunisawa², I. Regos³, D. Kawakami¹:

1 Shimadzu Europa GmbH, 2 Shimadzu Corporation, 3 RECIPE Chemicals + Instruments GmbH

24/7 fully automated therapeutic drug analysis for research projects by LC/MS/MS

Jaffuel A 1, Yoshikawa K 1, Streit F 2

1 Shimadzu Corporation Japan, Kyoto, Japan 

2 Department of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany

Use of therapeutic drug monitoring for continuous ampicillin therapy of critically ill patients

Weber L.1, Stephani C.2, Wieditz J 2,3., Streit F. 4, Scheithauer S. 5, Moerer O 2.

1 Clinic for Internal Medicine, University Medical Center Goettingen, Goettingen, Germany
2 Clinic for Anesthesiology, University Medical Center Goettingen, Goettingen, Germany
3 Department of Medical Statistics, University Medical Center Goettingen, Goettingen, Germany
4 Department of Clinical Chemistry,  University Medical Center Goettingen, Goettingen, Germany
5 Department of Infection Control and infectious diseases, University Medical Center Goettingen, Goettingen, Germany

Product lineup