Quan/Qual approaches using ultra fast capabilities

Expand your capabilities on Quan/Qual
 

Shimadzu is a global leader in ultra fast capabilities in mass spectrometry creating methods that are designed to overcome real-world obstacles and deliver better data.

High Sensitive and High Speed Forensic Screening

 

Ultra fast capabilities help to reshape workflows and help productivity by bringing together definitive quantitation and information rich MS/MS spectra in a single analysis. The LCMS-8060 can quickly switch between a full scan analysis and precise quantitation using the Synchronized Survey Scan (SSS) mode. This mode automatically performs product ion scanning once a pre-defined threshold has been exceeded. Qual/Quan methods can support a maximum of 1000 events in a single SSS methods.


Data acquisition method setting of synchronized survey scan using MRM as survey and product ion scan as dependent event  

 

Quan/Qual method set up for the analysis of benzodiazepines in blood. The SSS method in rapid toxicology screening method package combines MRM and MRM triggered product ion scanning for 161 compounds.

 

Blood samples were spiked with flunitrazepam at three concentration levels (0.1, 1.0 and 10 ng/mL) and pretreated by a simplified QuEChERS method. Flunitrazepam was precisely detected at two different scan speeds 3,000 u/sec and 30,000 u/sec. At a scan speed of 30,000 u/sec the LCMS-8060 acquires more data points over a peak without loss of mass accuracy or quantitative precision. In the case of the lower calibration standard at a concentration of 0.1 ng/mL the data quality of the product ion spectrum was still maintained at 30,000 u/sec.

 


Data acquisition method setting of synchronized survey scan using MRM as survey and product ion scan as dependent event

 

 

For Research Use Only. Not for use in diagnostic procedures.

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